Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies

S Tanabe, S Quader, H Cabral, R Ono - Frontiers in pharmacology, 2020 - frontiersin.org
The mechanism of epithelial-mesenchymal transition (EMT) consists of the cellular
phenotypic transition from epithelial to mesenchymal status. The cells exhibiting EMT exist in …

The involvement of exosomes in the diagnosis and treatment of pancreatic cancer

AN Ariston Gabriel, F Wang, Q Jiao, U Yvette, X Yang… - Molecular cancer, 2020 - Springer
At the moment, pancreatic cancer is among the deadliest gastrointestinal diseases, and
pancreatic cancer growth is a complex biological process that is based on different kinds of …

DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer

Y Zhang, R Kong, W Yang, K Hu, Z Zhao, L Li, X Geng… - Cancer Letters, 2023 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic tumor
microenvironment (TME), which aids tumor progression, drug resistance, and immune …

Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer

LF Sempere, K Powell, J Rana, AA Brock… - Cancer and Metastasis …, 2021 - Springer
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer with an
overall 5-year survival rate of less than 10%. The 1-year survival rate of patients with locally …

Subtype-specific and co-occurring genetic alterations in B-cell non-Hodgkin lymphoma

MCJ Ma, S Tadros, A Bouska, T Heavican… - …, 2021 - pmc.ncbi.nlm.nih.gov
B-cell non-Hodgkin lymphoma (B-NHL) encompasses multiple clinically and phenotypically
distinct subtypes of malignancy with unique molecular etiologies. Common subtypes of B …

S100A16 promotes metastasis and progression of pancreatic cancer through FGF19-mediated AKT and ERK1/2 pathways

D Fang, C Zhang, P Xu, Y Liu, X Mo, Q Sun… - Cell biology and …, 2021 - Springer
The S100 protein family genes play a crucial role in multiple stages of tumorigenesis and
progression. Most of S100 genes are located at chromosome locus 1q21, which is a region …

miRNAs in pancreatic cancer progression and metastasis

ETY Mok, JL Chitty, TR Cox - Clinical & Experimental Metastasis, 2024 - Springer
Small non-coding RNA or microRNA (miRNA) are critical regulators of eukaryotic cells.
Dysregulation of miRNA expression and function has been linked to a variety of diseases …

Liquid biopsy analysis of lipometabolic exosomes in pancreatic cancer

W Guo, P Ying, R Ma, Z Jing, G Ma, J Long, G Li… - Cytokine & Growth …, 2023 - Elsevier
Pancreatic cancer is characterized by its high malignancy, insidious onset and poor
prognosis. Most patients with pancreatic cancer are usually diagnosed at advanced stage or …

UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1

H Chen, L Li, J Hu, Z Zhao, L Ji, C Cheng… - Journal of Experimental …, 2019 - Springer
Background Ubiquitin-like protein 4A (UBL4A) plays a significant role in protein metabolism
and the maintenance of cellular homeostasis. In cancer, UBL4A represses tumorigenesis …

Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p

F Xia, Y Chen, B Jiang, N Bai, X Li - Cancer cell international, 2020 - Springer
Background Thyroid cancer is an endocrine malignancy that is growing in incidence
worldwide. Despite progress in diagnostics and treatment of thyroid cancer, prognosis …