The seven serotypes of botulinum toxin (BTX) produced by Clostridium botulinum exert their
paralytic effect by inhabiting acetylcholine release at the neuromuscular junction. Each of …

Metalloendopeptidases are present across all kingdoms of living organisms; they are
ubiquitous and widely involved in metabolism regulation through their ability either to …

Strains of Bacteroides fragilis associated with diarrheal disease (enterotoxigenic B. fragilis)
produce a 20-kDa zinc-dependent metalloprotease toxin (B. fragilis enterotoxin; BFT) that …

Synaptobrevins are vesicle-associated proteins implicated in neurotransmitter release by
both biochemical studies and perturbation experiments that use botulinum toxins. To test …

The cleavage of peptide bonds by metallopeptidases (MPs) is essential for life. These
ubiquitous enzymes participate in all major physiological processes, and so their …

The synaptic plasma membrane proteins syntaxin and synaptosome‐associated protein of
25 kDa (SNAP‐25) are central participants in synaptic vesicle trafficking and …

Studies of the pathogenesis of enterococcal infection are beginning to identify specific
enterococcal and host traits that contribute to the balanced commensal relationship, as well …

The emergence of bacterial pathogen resistance to common antibiotics strongly supports the
necessity to develop alternative mechanisms for combating drug-resistant forms of these …

Crystal structures of type B botulinum neurotoxin, determined under conditions relevant to
the extracellular binding and intracellular substrate cleavage steps of its toxic action, reveal …

Previous studies in this laboratory had mapped the immune recognition profile of the regions
recognized antibodies (Abs) and by T cells on the protective HC domain (C‐terminal …