Obesity and hyperlipidemia are the most prevalent independent risk factors of chronic
kidney disease (CKD), suggesting that lipid accumulation in the renal parenchyma is …

Neutrophils are essential to the homeostatic mission of safeguarding host tissues,
responding rapidly and diversely to breaches of the host's barriers to infection, and returning …

Neutrophils are implicated in multiple homeostatic and pathological processes, but whether
functional diversity requires discrete neutrophil subsets is not known. Here, we apply single …

Hematopoietic stem cells (HSCs) maintain life-long production of immune cells and can
directly respond to infection, but sustained effects on the immune response remain unclear …

Biallelic mutations of the CEBPA gene (CEBPA bi) define a distinct entity associated with
favorable prognosis; however, the role of monoallelic mutations (CEBPA sm) is poorly …

Delineating hierarchical cellular states, including rare intermediates and the networks of
regulatory genes that orchestrate cell-type specification, are continuing challenges for …

Post-translational modifications of histone proteins and exchanges of histone variants of
chromatin are central to the regulation of nearly all DNA-templated biological processes …

Granules are essential for the ability of neutrophils to fulfill their role in innate immunity.
Granule membranes contain proteins that react to environmental cues directing neutrophils …

Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …

Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and
functions. Currently, hematopoietic progenitors are defined using surface markers combined …