Enzymatic function and activity of proteases is closely controlled by the pH value. The
protonation states of titratable residues in the active site react to changes in the pH value …

Allergens are substances that cause abnormal immune responses and can originate from
various sources. IgE-mediated allergies are one of the most common and severe types of …

In response to varying light conditions, light-harvesting complexes (LHCs) switch from a light-
harvesting state to a quenched state to protect the photosynthetic organism from excessive …

Almost all biological reactions are pH-dependent and understanding the origin of pH
dependence requires knowledge of the pKa's of ionizable groups. Here, we report a new …

Electrostatic forces are important for protein folding and are favored targets of protein
engineering. However, interactions between charged residues are difficult to study because …

The family of profilin allergens is a common class of proteins found in plants, viruses and
various eukaryotes including mammals. Profilins are characterized by an evolutionary …

Susceptibility to endosomal degradation is a decisive contribution to a protein's
immunogenicity. It is assumed that the processing kinetics of structured proteins are …

Proteolytic susceptibility during endolysosomal degradation is decisive for allergic
sensitization. In the major birch pollen allergen Bet v 1 most protease cleavage sites are …

Understanding the relationship between protein structure and function is paramount to
gaining insight into important biological mechanisms. In this context, pH often plays a …