Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

Hereditary spastic paraplegia (HSP) is a group of clinically and genetically heterogeneous
neurological disorders characterized by pathophysiologic hallmark of length-dependent …

A large number of neurodegenerative diseases in humans result from protein misfolding and
aggregation. Protein misfolding is believed to be the primary cause of Alzheimer's disease …

The endoplasmic reticulum (ER) is a highly versatile protein factory that is equipped with
chaperones and folding enzymes essential for protein folding. ER quality control guided by …

Pelizaeus-Merzbacher disease (PMD) and its allelic disorder, spastic paraplegia type 2
(SPG2), are among the best-characterized dysmyelinating leukodystrophies of the central …

The expression of correctly folded and functional heterologous proteins is important in many
biotechnological production processes, whether it is enzymes, biopharmaceuticals or …

The endoplasmic reticulum (ER) is dedicated to import, folding and assembly of all proteins
that travel along or reside in the secretory pathway of eukaryotic cells. Folding in the ER is …

G protein-coupled receptors (GPCRs) are membrane proteins that traverse the plasma
membrane seven times (hence, are also called 7TM receptors). The polytopic structure of …

It has been estimated that up to one-third of the proteins encoded by the human genome
enter the endoplasmic reticulum (ER) as extended polypeptide chains where they undergo …

Calnexin (CANX) and calreticulin (CALR) are homologous lectin chaperones located in the
endoplasmic reticulum and cooperate to mediate nascent glycoprotein folding. In the testis …