Carnitine is a conditionally essential nutrient that plays a vital role in energy production and
fatty acid metabolism. Vegetarians possess a greater bioavailability than meat eaters …

Insulin sensitizers like metformin generally act through pathways triggered by adenosine
monophosphate‐activated protein kinase. Carnitine palmitoyltransferase 1 (CPT1) controls …

Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a
delectable piece of bacon-a small taste of high-fat foods often draws you back for more. But …

Overexpression of fatty acid synthase (FASN), a key regulator of the de novo synthesis of
fatty acids, has been demonstrated in a variety of cancers and is associated with poor …

Metabolic sensing neurons in the ventromedial hypothalamus (VMH) alter their activity when
ambient levels of metabolic substrates, such as glucose and fatty acids (FA), change. To …

We assessed the mechanisms by which specialized hypothalamic ventromedial nucleus
(VMN) neurons utilize both glucose and long-chain fatty acids as signaling molecules to …

Abstract Introduction Inhibiting the enzyme Fatty Acid Synthase (FASN) leads to apoptosis of
breast carcinoma cells, and this is linked to human epidermal growth factor receptor 2 …

Obesity and Type 2 diabetes are major worldwide public health issues today. A relationship
between total fat intake and obesity has been found. In addition, the mechanisms of long …

There is a myriad of enzymes within the body responsible for maintaining homeostasis by
providing the means to convert substrates to products as and when required. Physiological …

Purpose: Fatty acid synthase (FASN) is overexpressed in human breast carcinoma. The
natural polyphenol (−)-epigallocatechin-3-gallate blocks in vitro FASN activity and leads to …