Inert gas washout was first described more than 60 years ago and 2 principal tests have
been developed from it: the single breath and multiple breath washout (MBW) techniques …

Background: Obstructive airway disease is nonuniformly distributed throughout the bronchial
tree, although the extent to which this occurs can vary among conditions. The multiple …

Rationale: Cystic fibrosis (CF) lung disease starts in early infancy, suggesting that preventive
treatment may be most beneficial. Lung clearance index (LCI) and chest magnetic …

Accurate monitoring of flow rate and volume exchanges is essential to minimize ventilator-
induced lung injury. Mechanical ventilators employ flowmeters to estimate the amount of …

In the last few years there has been a growing interest in lung clearance index (LCI), a
measure of lung physiology derived from multiple breath washout tests. This resurgence of …

There is increasing evidence of the adverse impact of prenatal exposure to air pollution. This
is of particular interest, as exposure during pregnancy—a crucial time span of important …

Background For reliable assessment of ventilation inhomogeneity, multiple-breath washout
(MBW) systems should be realistically validated. We describe a new lung model for in vitro …

There is increasing interest in using the Multiple Breath Washout technique and the lung
clearance index (LCI) for detecting early pulmonary changes, for example, in cystic fibrosis …

Background The lung clearance index (LCI), measured by multiple breath washout (MBW),
reflects global ventilation inhomogeneity and is a sensitive marker of early cystic fibrosis …

Background In school-aged children with cystic fibrosis (CF) structural lung damage
assessed using chest CT is associated with abnormal ventilation distribution. The primary …