[HTML][HTML] Interferon-stimulated genes as enhancers of antiviral innate immune signaling

KM Crosse, EA Monson, MR Beard… - Journal of innate …, 2018 - karger.com
The ability of a host to curb a viral infection is heavily reliant on the effectiveness of an initial
antiviral innate immune response, resulting in the upregulation of interferon (IFN) and …

Direct antiviral mechanisms of interferon-gamma

S Kang, HM Brown, S Hwang - Immune network, 2018 - synapse.koreamed.org
Interferon-gamma (IFNG) is a pleiotropic cytokine that modulates both innate and adaptive
immune networks; it is the most potent activator of macrophages and a signature cytokine of …

microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

P Schult, H Roth, RL Adams, C Mas, L Imbert… - Nature …, 2018 - nature.com
Abstract The liver-specific microRNA-122 (miR-122) recognizes two conserved sites at the
5′ end of the hepatitis C virus (HCV) genome and contributes to stability, translation, and …

DEAD/H-box helicases: Anti-viral and pro-viral roles during infections

R Ullah, J Li, P Fang, S Xiao, L Fang - Virus Research, 2022 - Elsevier
Abstract DEAD/H-box RNA helicases make the prominent family of helicases super family-2
which take part in almost all RNA-related processes, from initiation of transcription to RNA …

DEAD-box helicases: sensors, regulators, and effectors for antiviral defense

F Taschuk, S Cherry - Viruses, 2020 - mdpi.com
DEAD-box helicases are a large family of conserved RNA-binding proteins that belong to
the broader group of cellular DExD/H helicases. Members of the DEAD-box helicase family …

DExD/H-box helicases: multifunctional regulators in antiviral innate immunity

C Su, Y Tang, C Zheng - Cellular and Molecular Life Sciences, 2022 - Springer
DExD/H-box helicases play critical roles in multiple cellular processes, including
transcription, cellular RNA metabolism, translation, and infections. Several seminal studies …

DExH/D-box helicases at the frontline of intrinsic and innate immunity against viral infections

B Bonaventure, C Goujon - Journal of General Virology, 2022 - microbiologyresearch.org
DExH/D-box helicases are essential nucleic acid and ribonucleoprotein remodelers
involved in all aspects of nucleic acid metabolism including replication, gene expression …

Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution

RE Hamlin, SM Pienkos, L Chan, MA Stabile… - Science Translational …, 2024 - science.org
Sex differences have been observed in acute coronavirus disease 2019 (COVID-19) and
Long Covid (LC) outcomes, with greater disease severity and mortality during acute infection …

Comparative analysis of African and Asian lineage-derived Zika virus strains reveals differences in activation of and sensitivity to antiviral innate immunity

K Esser-Nobis, LD Aarreberg, JA Roby… - Journal of …, 2019 - Am Soc Microbiol
In recent years, Asian lineage Zika virus (ZIKV) strains emerged to cause pandemic
outbreaks associated with a high rate of congenital ZIKV syndrome (CZVS). The reasons for …

Multi–cell type gene coexpression network analysis reveals coordinated interferon response and cross–cell type correlations in systemic lupus erythematosus

B Panwar, BJ Schmiedel, S Liang, B White… - Genome …, 2021 - genome.cshlp.org
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately
affecting women. A major obstacle in finding targeted therapies for SLE is its remarkable …