Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Metals in Alzheimer's disease

M Babić Leko, L Langer Horvat, E Španić Popovački… - Biomedicines, 2023 - mdpi.com
The role of metals in the pathogenesis of Alzheimer's disease (AD) is still debated. Although
previous research has linked changes in essential metal homeostasis and exposure to …

Active form of vitamin D analogue mitigates neurodegenerative changes in Alzheimer's disease in rats by targeting Keap1/Nrf2 and MAPK-38p/ERK signaling …

SS El-Din, L Rashed, E Medhat, BE Aboulhoda… - Steroids, 2020 - Elsevier
Background The nuclear factor erythroid2-related factor2 (Nrf2), a chief transcriptional
regulator of antioxidant response element (ARE), is considered a promising target for the …

[Retracted] Effect of Resveratrol Combined with Donepezil Hydrochloride on Inflammatory Factor Level and Cognitive Function Level of Patients with Alzheimer's …

X Fang, J Zhang, J Zhao, L Wang - Journal of Healthcare …, 2022 - Wiley Online Library
Objective. To explore the effect of resveratrol (RES) combined with donepezil hydrochloride
on inflammatory factor level and cognitive function level of patients with Alzheimer's disease …

Serum calcium predicts cognitive decline and clinical progression of Alzheimer's disease

LZ Ma, ZX Wang, ZT Wang, XH Hou, XN Shen… - Neurotoxicity …, 2021 - Springer
Relationship between serum calcium and Alzheimer's disease (AD) remains unclear. The
aim of this study is to test whether serum calcium is associated with other AD-associated …

Impact of serum calcium levels on Alzheimer's disease: a Mendelian randomization study

Y He, H Zhang, T Wang, Z Han, Q Ni… - Journal of …, 2020 - content.iospress.com
Background: Altered calcium homeostasis is hypothesized to underlie Alzheimer's disease
(AD). However, it remains unclear whether serum calcium levels are genetically associated …

Therapeutic potential of porcine liver decomposition product: new insights and perspectives for microglia-mediated neuroinflammation in neurodegenerative diseases

T Tsukahara, H Haniu, T Uemura, Y Matsuda - Biomedicines, 2020 - mdpi.com
It is widely accepted that microglia-mediated inflammation contributes to the progression of
neurodegenerative diseases; however, the precise mechanisms through which these cells …

Data‐driven stochastic model for quantifying the interplay between amyloid‐beta and calcium levels in Alzheimer's disease

H Shaheen, R Melnik, S Singh… - … Analysis and Data …, 2024 - Wiley Online Library
The abnormal aggregation of extracellular amyloid‐β (A β)\left (A β\right) in senile plaques
resulting in calcium Ca+ 2\left (Ca^+ 2\right) dyshomeostasis is one of the primary symptoms …

Health effects of calcium: evidence from Mendelian randomization studies

Y Chen, V Forgetta, JB Richards… - Journal of Bone and …, 2021 - academic.oup.com
Calcium is widely used in conjunction with vitamin D to prevent osteoporosis. The use of
calcium supplementation is also promoted for its potential benefits in lowering the risk for …

An updated mendelian randomization analysis of the association between serum calcium levels and the risk of alzheimer's disease

Y Shi, R Liu, Y Guo, Q Li, H Zhou, S Yu, H Liang… - Frontiers in …, 2021 - frontiersin.org
It has been a long time that the relationship between serum calcium levels and Alzheimer's
disease (AD) remains unclear. Until recently, observational studies have evaluated the …