Light sheet fluorescence microscopy (LSFM) uses a thin sheet of light to excite only
fluorophores within the focal volume. Light sheet microscopes (LSMs) have a true optical …

In comparison with 2D cell culture models, 3D spheroids are able to accurately mimic some
features of solid tumors, such as their spatial architecture, physiological responses …

The common and persistent failures to translate promising preclinical drug candidates into
clinical success highlight the limited effectiveness of disease models currently used in drug …

This paper is intended to give a comprehensive review of light-sheet (LS) microscopy from
an optics perspective. As such, emphasis is placed on the advantages that LS microscope …

Academic research plays a key role in identifying new drug targets, including understanding
target biology and links between targets and disease states. To lead to new drugs, however …

The preclinical drug screening of pancreatic cancer treatments suffers from the absence of
appropriate models capable to reproduce in vitro the heterogeneous tumor …

The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …

Deep tissue chemical imaging has a vital role in biological and medical applications.
Current approaches suffer from water absorption and tissue scattering, which limits imaging …

This article focuses on how nanoparticle shape affects the cellular internalisation and
transport of nanoparticles inside cells and what the different analytical methods for …

Evaluation of cancer therapeutics by utilizing 3D tumor models, before clinical studies, could
be more advantageous than conventional 2D tumor models (monolayer cultures). The 3D …