Sensory processing deficits and related cortical pathological changes in Alzheimer's disease

NK Zhang, SK Zhang, LI Zhang, HW Tao… - Frontiers in Aging …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily affecting
cognitive functions. However, sensory deficits in AD start to draw attention due to their high …

[HTML][HTML] A more holistic perspective of Alzheimer's disease: roles of gut microbiome, adipocytes, HPA axis, melatonergic pathway and astrocyte mitochondria in the …

G Anderson - Frontiers in Bioscience-Landmark, 2023 - imrpress.com
Alzheimer's disease is widely regarded as poorly treated due to poor conceptualization. For
40 years, Alzheimer's disease pathophysiology has focused on two culprits, amyloid-β …

Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer's …

CH Poon, STN Wong, J Roy, Y Wang, HWH Chan… - Cells, 2023 - mdpi.com
A promising direction in the research on Alzheimer's Disease (AD) is the identification of
biomarkers that better inform the disease progression of AD. However, the performance of …

Preserved blood-brain barrier and neurovascular coupling in female 5xFAD model of Alzheimer's disease

O Zhukov, C He, R Soylu-Kucharz, C Cai… - Frontiers in Aging …, 2023 - frontiersin.org
Introduction Dysfunction of the cerebral vasculature is considered one of the key
components of Alzheimer's disease (AD), but the mechanisms affecting individual brain …

Damage to the Locus Coeruleus Alters the Expression of Key Proteins in Limbic Neurodegeneration

F Biagioni, M Ferrucci, G Lazzeri, M Scioli… - International Journal of …, 2024 - mdpi.com
The present investigation was designed based on the evidence that, in neurodegenerative
disorders, such as Alzheimer's dementia (AD) and Parkinson's disease (PD), damage to the …

Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model

B Gurdon, SC Yates, G Csucs, NE Groeneboom… - Communications …, 2024 - nature.com
Alzheimer's disease (AD) is broadly characterized by neurodegeneration, pathology
accumulation, and cognitive decline. There is considerable variation in the progression of …

Leveraging genetic diversity in mice to inform individual differences in brain microstructure and memory

TJ Murdy, AR Dunn, S Singh… - Frontiers in behavioral …, 2023 - frontiersin.org
In human Alzheimer's disease (AD) patients and AD mouse models, both differential pre-
disease brain features and differential disease-associated memory decline are observed …

A Comprehensive Review on the Progress and Challenges of Tetrahydroisoquinoline Derivatives as a Promising Therapeutic Agent to Treat Alzheimer's Disease.

D Thangeswaran, S Shamsuddin, V Balakrishnan - Heliyon, 2024 - cell.com
Alzheimer's disease (AD) is the most common and irreversible neurodegenerative disorder
worldwide. While the precise mechanism behind this rapid progression and multifaceted …

Exploring the Therapeutic Potential of BBB‐Penetrating Phytochemicals With p38 MAPK Modulatory Activity in Addressing Oxidative Stress‐Induced …

A Hosseini, M Sheibani, M Valipour - Phytotherapy Research, 2024 - Wiley Online Library
Oxidative stress plays an important role in the occurrence of neurodegenerative diseases.
Previous studies indicate a strong connection between oxidative stress, inappropriate …

BLA-involved circuits in neuropsychiatric disorders

LH Ma, S Li, XH Jiao, ZY Li, Y Zhou, CR Zhou… - Ageing Research …, 2024 - Elsevier
The basolateral amygdala (BLA) is the subregion of the amygdala located in the medial of
the temporal lobe, which is connected with a wide range of brain regions to achieve diverse …