Over the last decades, incrementally improved xenograft mouse models, supporting the
engraftment and development of a human hemato-lymphoid system, have been developed …

Xenotransplantation of patient-derived samples in mouse models has been instrumental in
depicting the role of hematopoietic stem and progenitor cells in the establishment as well as …

Implanted biomaterials often fail because they elicit a foreign body response (FBR) and
concomitant fibrotic encapsulation. To design clinically relevant interference approaches, it …

Pure iron (Fe) has been investigated as a cardiovascular stent in recent years for its
biodegradation property and blood compatibility. It also has great potential for bone healing …

New regenerative materials and approaches need to be assessed through reliable and
comparable methods for rapid translation to the clinic. There is a considerable need for …

Biomaterials, biomedical devices and engineered cell grafts can be implanted to restitute
tissue anatomy and function. Such implants can either integrate physiologically, with no or …

Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in
muscles surrounding joints following spinal cord or brain injury. We investigated the …

Current in vivo models for investigating human primary bone tumors and cancer metastasis
to the bone rely on the injection of human cancer cells into the mouse skeleton. This …

Cell therapies and regenerative medicine interventions require an adequate source of
therapeutic cells. Here, we demonstrate that constructing in vivo osteo-organoids by …

The human bone marrow (hBM) is a complex organ critical for hematopoietic and immune
homeostasis, and where many cancers metastasize. Understanding the fundamental …