RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Present review highlights various drug delivery systems used for delivery of pharmaceutical
agents mainly antibiotics, antineoplastic agents, neuropeptides, and other therapeutic …

Cancer immunotherapy has shown remarkable progress in recent years. Nanocarriers, such
as liposomes, have favorable advantages with the potential to further improve cancer …

Efficient gene therapy is mainly dependent on the gene transfer capability of gene delivery
vectors. Non-viral vectors have become the research interest of many researchers because …

In vitro transcribed mRNA constitutes a versatile platform to encode antigens and to evoke
CD8 T-cell responses. Systemic delivery of mRNA packaged into cationic liposomes …

Abstract Initially, the Atherton–Todd (AT) reaction was applied for the synthesis of
phosphoramidates by reacting dialkyl phosphite with a primary amine in the presence of …

MicroRNAs (miRNAs) are short (~ 21–23 nucleotides), non-coding endogenous RNA
molecules that modulate gene expression at the post-transcriptional level via the …

In recent years, nanomaterials have been widely applied as advanced drug and gene
delivery nanosystems. Among them, solid lipid nanoparticles (SLNs) have attracted great …

Self-amplifying replicon RNA (RepRNA) are large molecules (12-14 kb); their self-replication
amplifies mRNA template numbers, affording several rounds of antigen production …

Alzheimer's disease (AD) is a form of dementia with high impact worldwide, accounting with
more than 46 million cases. It is estimated that the number of patients will be four times …