Necroptosis is a form of programmed necrosis that is mediated by various cytokines and
pattern recognition receptors (PRRs). Cells dying by necroptosis show necrotic phenotypes …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

How glucose metabolism remodels pro-tumor functions of tumor-associated macrophages
(TAMs) needs further investigation. Here we show that M2-like TAMs bear the highest …

In the mid-1980s, the identification of serine and threonine residues on nuclear and
cytoplasmic proteins modified by a N-acetylglucosamine moiety (O-GlcNAc) via an O …

Protein O-linked β-N-acetylglucosamine (O-GlcNAc) modification (O-GlcNAcylation) is a
unique monosaccharide modification discovered in the early 1980s. With the technological …

Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated
immune responses and multiple organ dysfunction. The imbalance between …

Glucose metabolism and innate immunity evolved side-by-side. It is unclear if and how the
two systems interact with each other during hepatitis B virus (HBV) infections and, if so …

In this study, we demonstrated an essential function of the hexosamine biosynthesis
pathway (HBP)–associated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling in …

Post-translational modification with O-linked β-N-acetylglucosamine (O-GlcNAc), a process
referred to as O-GlcNAcylation, occurs on a vast variety of proteins. Mounting evidence in …

Necroptosis is a caspase-independent, lytic form of programmed cell death whose errant
activation has been widely implicated in many pathologies. The pathway relies on the …