[HTML][HTML] Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

L Bergdolt, A Dunaevsky - Progress in neurobiology, 2019 - Elsevier
The developing brain is sensitive to a variety of insults. Epidemiological studies have
identified prenatal exposure to infection as a risk factor for a range of neurological disorders …

Maternal immune activation by poly I: C as a preclinical model for neurodevelopmental disorders: a focus on autism and schizophrenia

FL Haddad, SV Patel, S Schmid - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Maternal immune activation (MIA) in response to a viral infection during early and mid-
gestation has been linked through various epidemiological studies to a higher risk for the …

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies

S Giovanoli, U Weber-Stadlbauer… - Brain, behavior, and …, 2016 - Elsevier
Prenatal exposure to infectious or inflammatory insults can increase the risk of developing
neuropsychiatric disorder in later life, including schizophrenia, bipolar disorder, and autism …

Effects of immune activation during early or late gestation on schizophrenia-related behaviour in adult rat offspring

C Meehan, L Harms, JD Frost, R Barreto, J Todd… - Brain, behavior, and …, 2017 - Elsevier
Maternal exposure to infectious agents during gestation has been identified as a significant
risk factor for schizophrenia. Using a mouse model, past work has demonstrated that the …

Late prenatal immune activation causes hippocampal deficits in the absence of persistent inflammation across aging

S Giovanoli, T Notter, J Richetto, MA Labouesse… - Journal of …, 2015 - Springer
Background Prenatal exposure to infection and/or inflammation is increasingly recognized to
play an important role in neurodevelopmental brain disorders. It has recently been …

Sex differences in the effect of maternal immune activation on cognitive and psychosis‐like behaviour in Long Evans rats

A Gogos, A Sbisa, D Witkamp… - European Journal of …, 2020 - Wiley Online Library
Maternal immune activation during pregnancy is associated with increased risk of
development of schizophrenia in later life. There are sex differences in schizophrenia …

Kinesin Kif3b mutation reduces NMDAR subunit NR2A trafficking and causes schizophrenia‐like phenotypes in mice

AH Alsabban, M Morikawa, Y Tanaka, Y Takei… - The EMBO …, 2020 - embopress.org
The transport of N‐methyl‐d‐aspartate receptors (NMDAR s) is crucial for neuronal plasticity
and synapse formation. Here, we show that KIF 3B, a member of the kinesin superfamily …

Inflammation and the developing brain: consequences for hippocampal neurogenesis and behavior

HF Green, YM Nolan - Neuroscience & Biobehavioral Reviews, 2014 - Elsevier
While the detrimental impact of inflammation on adult hippocampal neurogenesis and
associated behaviors has recently gained credence, the effects of inflammation on the …

Behavioral alterations in rat offspring following maternal immune activation and ELR-CXC chemokine receptor antagonism during pregnancy: implications for …

SA Ballendine, Q Greba, W Dawicki, X Zhang… - Progress in Neuro …, 2015 - Elsevier
Research suggests that maternal immune activation (MIA) during pregnancy increases the
risk of neurodevelopmental disorders including schizophrenia and autism in the offspring …

Enhancing NMDA receptor function: recent progress on allosteric modulators

L Yao, Q Zhou - Neural Plasticity, 2017 - Wiley Online Library
The N‐methyl‐D‐aspartate receptors (NMDARs) are subtype glutamate receptors that play
important roles in excitatory neurotransmission and synaptic plasticity. Their hypo‐or …