Accurate descriptions of protein-protein interactions are essential for understanding
biological systems. Remarkably accurate atomic structures have been recently computed for …

Residue coevolution estimations coupled to machine learning methods are revolutionizing
the ability of protein structure prediction approaches to model proteins that lack clear …

Multihaem cytochromes c are widespread in nature where they perform numerous roles in
diverse anaerobic metabolic pathways. This is achieved in two ways: multihaem …

Although the individual structures and respiratory functions of cytochromes are well studied,
the structural basis for their assembly, including transport of heme for attachment, are …

Cytochromes c use heme as a cofactor to carry electrons in respiration and photosynthesis.
The cytochrome c maturation system I, consisting of eight membrane proteins …

Membrane proteins play crucial roles in various cellular processes, and their interactions
with other proteins in and on the membrane are essential for their proper functioning. While …

Cytochromes c are ubiquitous heme proteins in mitochondria and bacteria, all possessing a
CXXCH (CysXxxXxxCysHis) motif with covalently attached heme. We describe the first in …

Heme trafficking is a fundamental biological process, yet its direct study has been hampered
due to heme's tight intracellular regulation, heme cytotoxicity, and the transient nature of …

Heme trafficking is essential for cellular function, yet mechanisms of transport and/or heme
interaction are not well defined. The System I and System II bacterial cytochrome c …

Rosa sterilis (RS) is a characteristic fruit in southwestern China that has numerous health
benefits; however, its pharmacological effect needs further clarification, especially with …