Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

J Wesolowski, V Alzogaray, J Reyelt, M Unger… - Medical microbiology …, 2009 - Springer
Antibodies are important tools for experimental research and medical applications. Most
antibodies are composed of two heavy and two light chains. Both chains contribute to the …

Ferritin: a versatile building block for bionanotechnology

G Jutz, P van Rijn, B Santos Miranda… - Chemical reviews, 2015 - ACS Publications
Nature is a great source of inspiration in solving extremely complex problems, and it is every
day more common to use its strategies for the development of new materials, methods, and …

Bioengineering strategies for protein-based nanoparticles

D Diaz, A Care, A Sunna - Genes, 2018 - mdpi.com
In recent years, the practical application of protein-based nanoparticles (PNPs) has
expanded rapidly into areas like drug delivery, vaccine development, and biocatalysis …

Endowing a ferritin‐like cage protein with high affinity and selectivity for certain inorganic materials

KI Sano, K Ajima, K Iwahori, M Yudasaka, S Iijima… - Small, 2005 - Wiley Online Library
Ferritin is a cage-shaped protein with a nanometer-sized interior space (7–8 nm in
diameter),[1] in which a variety of inorganic nanoparticles including oxidized Fe,[2] oxidized …

The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord

YL Petracca, MM Sartoretti, DJ Di Bella… - …, 2016 - journals.biologists.com
Considerable progress has been made in understanding the mechanisms that control the
production of specialized neuronal types. However, how the timing of differentiation …

Vaxjo: a web‐based vaccine adjuvant database and its application for analysis of vaccine adjuvants and their uses in vaccine development

S Sayers, G Ulysse, Z Xiang… - BioMed Research …, 2012 - Wiley Online Library
Vaccine adjuvants are compounds that enhance host immune responses to co‐
administered antigens in vaccines. Vaxjo is a web‐based central database and analysis …

[HTML][HTML] Second career of a biosynthetic enzyme: Lumazine synthase as a virus-like nanoparticle in vaccine development

R Ladenstein, E Morgunova - Biotechnology Reports, 2020 - Elsevier
Naturally occurring and computationally ab initio designed protein cages can now be
considered as extremely suitable materials for new developments in nanotechnology. Via …

A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis …

J Cassataro, KA Pasquevich, SM Estein, DA Laplagne… - Vaccine, 2007 - Elsevier
The development of an effective subunit vaccine against brucellosis is a research area of
intense interest. The enzyme lumazine synthase from Brucella spp.(BLS) is highly …

Immunization with a chimera consisting of the B subunit of Shiga toxin type 2 and brucella lumazine synthase confers total protection against Shiga toxins in mice

MP Mejias, G Ghersi, PO Craig, CA Panek… - The Journal of …, 2013 - journals.aai.org
The striking feature of enterohemorrhagic Escherichia coli (EHEC) infections is the
production of Shiga toxins (Stx) implicated in the development of the life-threatening …

A TLR4 agonist improves immune checkpoint blockade treatment by increasing the ratio of effector to regulatory cells within the tumor microenvironment

A Farias, A Soto, F Puttur, CJ Goldin, S Sosa, C Gil… - Scientific Reports, 2021 - nature.com
Brucella lumazine synthase (BLS) is a homodecameric protein that activates dendritic cells
via toll like receptor 4, inducing the secretion of pro-inflammatory cytokines and chemokines …