Cardiovascular diseases (CVDs), such as ischaemic heart disease, cardiomyopathy,
atherosclerosis, hypertension, stroke and heart failure, are among the leading causes of …

Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

Herein, we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy
(DCM) by examining the expression of key regulators of ferroptosis in mice with DCM and a …

Objectives: Intervertebral disc degeneration (IDD) is widely accepted as a cause of low back
pain and related degenerative musculoskeletal disorders. Nucleus pulposus (NP) cell …

Myocardial ischemia–reperfusion (MI/R) injury is characterized by iron deposition and
reactive oxygen species production, which can induce ferroptosis. Ferroptosis has also been …

Myocardial contractile dysfunction is associated with an increase in mitochondrial fission in
patients with diabetes. However, whether mitochondrial fission directly promotes diabetes …

Canagliflozin (Cana), an anti-diabetes drug belongs to sodium-glucose cotransporter 2
inhibitor, is gaining interest because of its extra cardiovascular benefits. Ferroptosis is a new …

Background. Diabetic cardiomyopathy (DCM) is a major threat for diabetic patients. Silent
information regulator 1 (SIRT1) has a regulatory effect on mitochondrial dynamics, which is …

Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important
mechanism involved in the pathogenesis of cardiovascular diseases including heart failure …

Recent evidence shows that resveratrol (RSV) may ameliorate high-glucose-induced
cardiac oxidative stress, mitochondrial dysfunction and myocardial fibrosis in diabetes …