The origin and evolution of cell types
Cell types are the basic building blocks of multicellular organisms and are extensively
diversified in animals. Despite recent advances in characterizing cell types, classification …
diversified in animals. Despite recent advances in characterizing cell types, classification …
Physiology and pathophysiology of itch
F Cevikbas, EA Lerner - Physiological reviews, 2020 - journals.physiology.org
Itch is a topic to which everyone can relate. The physiological roles of itch are increasingly
understood and appreciated. The pathophysiological consequences of itch impact quality of …
understood and appreciated. The pathophysiological consequences of itch impact quality of …
ASCL1 is a lineage oncogene providing therapeutic targets for high-grade neuroendocrine lung cancers
A Augustyn, M Borromeo, T Wang… - Proceedings of the …, 2014 - National Acad Sciences
Aggressive neuroendocrine lung cancers, including small cell lung cancer (SCLC) and non-
small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for …
small cell lung cancer (NSCLC), represent an understudied tumor subset that accounts for …
Making sense out of spinal cord somatosensory development
HC Lai, RP Seal, JE Johnson - Development, 2016 - journals.biologists.com
The spinal cord integrates and relays somatosensory input, leading to complex motor
responses. Research over the past couple of decades has identified transcription factor …
responses. Research over the past couple of decades has identified transcription factor …
Pioneer factor ASCL1 cooperates with the mSWI/SNF complex at distal regulatory elements to regulate human neural differentiation
Pioneer transcription factors are thought to play pivotal roles in developmental processes by
binding nucleosomal DNA to activate gene expression, though mechanisms through which …
binding nucleosomal DNA to activate gene expression, though mechanisms through which …
Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis
AASF Raposo, FF Vasconcelos, D Drechsel, C Marie… - Cell reports, 2015 - cell.com
The proneural transcription factor Ascl1 coordinates gene expression in both proliferating
and differentiating progenitors along the neuronal lineage. Here, we used a cellular model …
and differentiating progenitors along the neuronal lineage. Here, we used a cellular model …
Mechanisms of binding specificity among bHLH transcription factors
The transcriptome of every cell is orchestrated by the complex network of interaction
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …
between transcription factors (TFs) and their binding sites on DNA. Disruption of this network …
From signalling to form: the coordination of neural tube patterning
TJR Frith, J Briscoe, GLM Boezio - Current topics in developmental biology, 2024 - Elsevier
The development of the vertebrate spinal cord involves the formation of the neural tube and
the generation of multiple distinct cell types. The process starts during gastrulation …
the generation of multiple distinct cell types. The process starts during gastrulation …
Transcriptional selectors, masters, and combinatorial codes: regulatory principles of neural subtype specification
The broad range of tissue and cellular diversity of animals is generated to a large extent by
the hierarchical deployment of sequence‐specific transcription factors and co‐factors …
the hierarchical deployment of sequence‐specific transcription factors and co‐factors …
[HTML][HTML] The dorsal spinal cord and hindbrain: From developmental mechanisms to functional circuits
LR Hernandez-Miranda, T Müller, C Birchmeier - Developmental biology, 2017 - Elsevier
Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and
relaying sensory perception and participate in the coordination of sensory-motor output …
relaying sensory perception and participate in the coordination of sensory-motor output …