Germline mutations in the BRCA1 or BRCA2 tumour-suppressor genes are strong predictors
of breast and/or ovarian cancer development. The contribution of these mutations to breast …

Hereditary breast and ovarian cancer due to mutations in the BRCA1 and BRCA2 genes is
the most common cause of hereditary forms of both breast and ovarian cancer. The overall …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires
accurate, prospective cancer risk estimates. Objectives To estimate age-specific risks of …

Background Reliable estimates of cancer risk are critical for guiding management of BRCA1
and BRCA2 mutation carriers. The aims of this study were to derive penetrance estimates for …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context …

Risks of breast and ovarian cancer were determined for Ashkenazi Jewish women with
inherited mutations in the tumor suppressor genes BRCA1 and BRCA2. We selected 1008 …

Purpose Genetic counseling is now routinely offered to individuals at high risk of carrying a
BRCA1 or BRCA2 mutation. Risk prediction provided by the counselor requires reliable …

An Erratum has been published for this article in Statistics in Medicine 2005; 24 (1): 156.
Please note that the corresponding author's e‐mail address has now changed. For further …

BACKGROUND & AIMS:: Germline mutations in CDH1 are known to cause hereditary
diffuse gastric cancer (HDGC). Breast and colorectal cancer have also been reported in …

Background: Increasing numbers of BRCA1 mutation carriers are being identified in cancer
risk evaluation programs. However, no estimates of cancer risk specific to a clinic-based …