Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
Cortico-basal ganglia plasticity in motor learning
RH Roth, JB Ding - Neuron, 2024 - cell.com
One key function of the brain is to control our body's movements, allowing us to interact with
the world around us. Yet, many motor behaviors are not innate but require learning through …
the world around us. Yet, many motor behaviors are not innate but require learning through …
Preserved neural dynamics across animals performing similar behaviour
Animals of the same species exhibit similar behaviours that are advantageously adapted to
their body and environment. These behaviours are shaped at the species level by selection …
their body and environment. These behaviours are shaped at the species level by selection …
[HTML][HTML] High-density single-unit human cortical recordings using the Neuropixels probe
The action potential is a fundamental unit of neural computation. Even though significant
advances have been made in recording large numbers of individual neurons in animal …
advances have been made in recording large numbers of individual neurons in animal …
Pyramidal cell types drive functionally distinct cortical activity patterns during decision-making
Understanding how cortical circuits generate complex behavior requires investigating the
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …
cell types that comprise them. Functional differences across pyramidal neuron (PyN) types …
[HTML][HTML] Corticostriatal pathways for bilateral sensorimotor functions
R Gómez-Ocádiz, G Silberberg - Current Opinion in Neurobiology, 2023 - Elsevier
Corticostriatal pathways are essential for a multitude of motor, sensory, cognitive, and
affective functions. They are mediated by cortical pyramidal neurons, roughly divided into …
affective functions. They are mediated by cortical pyramidal neurons, roughly divided into …
Layer 5 intratelencephalic neurons in the motor cortex stably encode skilled movement
The primary motor cortex (M1) and the dorsal striatum play a critical role in motor learning
and the retention of learned behaviors. Motor representations of corticostriatal ensembles …
and the retention of learned behaviors. Motor representations of corticostriatal ensembles …
Neocortical layer 5 subclasses: from cellular properties to roles in behavior
S Moberg, N Takahashi - Frontiers in Synaptic Neuroscience, 2022 - frontiersin.org
Layer 5 (L5) serves as the main output layer of cortical structures, where long-range
projecting pyramidal neurons broadcast the columnar output to other cortical and …
projecting pyramidal neurons broadcast the columnar output to other cortical and …
[HTML][HTML] Integrating across behaviors and timescales to understand the neural control of movement
The nervous system evolved to enable navigation throughout the environment in the pursuit
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …
of resources. Evolutionarily newer structures allowed increasingly complex adaptations but …
Rethinking the network determinants of motor disability in Parkinson's disease
For roughly the last 30 years, the notion that striatal dopamine (DA) depletion was the critical
determinant of network pathophysiology underlying the motor symptoms of Parkinson's …
determinant of network pathophysiology underlying the motor symptoms of Parkinson's …