Rho-proteins and downstream pathways as potential targets in sepsis and septic shock: what have we learned from basic research

MLS Hahmeyer, JE da Silva-Santos - Cells, 2021 - mdpi.com
Sepsis and septic shock are associated with acute and sustained impairment in the function
of the cardiovascular system, kidneys, lungs, liver, and brain, among others. Despite the …

Rho‐kinase inhibitor Y‐27632 facilitates the proliferation, migration and pluripotency of human periodontal ligament stem cells

T Wang, W Kang, L Du, S Ge - Journal of cellular and molecular …, 2017 - Wiley Online Library
The selective in vitro expansion and differentiation of multipotent stem cells are critical steps
in cell‐based regenerative therapies, while technical challenges have limited cell yield and …

Rho kinase inhibition maintains intestinal and vascular barrier function by upregulation of occludin in experimental necrotizing enterocolitis

JS Grothaus, G Ares, C Yuan… - American Journal of …, 2018 - journals.physiology.org
Necrotizing enterocolitis (NEC) is a deadly disease that occurs in 5–10% of neonates.
Although NEC has been extensively studied, no single therapeutic target has been …

Effect of simvastatin on the intestinal Rho/ROCK signaling pathway in rats with sepsis

Y Wang, X Wang, W Yang, X Zhao, R Zhang - Journal of Surgical Research, 2018 - Elsevier
Background Simvastatin may alleviate the intestinal barrier dysfunction induced by sepsis.
This study aimed to investigate the role of the Ras homolog (Rho)/Rho-associated coiled …

α-Lipoic acid vaginal administration contrasts inflammation and preterm delivery in rats

SC Micili, A Goker, K Kuscu, BU Ergur… - Reproductive …, 2019 - journals.sagepub.com
α-Lipoic acid (ALA) is a safe natural molecule involved in the immunomodulation of many
physiological processes. Orally administered ALA has been reported to treat several …

An aligned nanofiber nerve conduit that inhibits painful traumatic neuroma formation through regulation of the RhoA/ROCK signaling pathway

X Zhou, B Zhao, K Poonit, W Weng, C Yao, C Sun… - Journal of …, 2019 - thejns.org
OBJECTIVE Traumatic neuromas represent a prevalent source of neuropathic pain. As of
yet, there has been no single treatment method that can guarantee permanent relief of …

The Rho kinase inhibitor Y-27632 facilitates the differentiation of bone marrow mesenchymal stem cells

X Liu, Z Zhang, X Yan, H Liu, L Zhang, A Yao… - Journal of molecular …, 2014 - Springer
The selective in vitro expansion and differentiation of multipotent stem cells are critical steps
in cell-based regenerative therapies, but technical challenges have limited cell yield and …

Inhibiting the ROCK pathway ameliorates acute lung injury in mice following myocardial ischemia/reperfusion

SD Liu, Y Timur, L Xu, WX Meng, B Sun… - Immunological …, 2022 - Taylor & Francis
To clarify the role of Y-27632, a selective inhibitor of Rho-associated coiled-coil forming
protein kinase (ROCK), in acute lung injury (ALI) induced by myocardial …

Epigenetic upregulation of ssc-miR-124a following treatment with Clostridium perfringens beta2-toxin attenuates both apoptosis and inflammation in intestinal porcine …

X Gao, Q Yang, S Zhang, X Huang, Z Yan… - Archives of Biochemistry …, 2021 - Elsevier
Clostridium perfringens (C. perfringens) is a globally recognized zoonotic pathogen. It has
been reported that the beta2-toxin produced by C. perfringens can cause a variety of …

ROCKing the field of intestinal fibrosis or between a ROCK and a hard place?

F Rieder - Gastroenterology, 2017 - gastrojournal.org
Intestinal fibrosis remains one of the largest clinical challenges in the field of inflammatory
bowel diseases. 1 More than one-half of the patients with Crohn's disease develop clinically …