Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …

Tobacco use is a major cause of preventable morbidity and mortality globally. Tobacco
products, including smokeless tobacco (ST), generally contain tobacco-specific N …

Genetically engineered mouse models only capture a small fraction of the genetic lesions
that drive human cancer. Current CRISPR–Cas9 models can expand this fraction but are …

Recent changes in the classification of cervical adenocarcinomas have re-categorized
serous carcinoma as potentially nonexistent. However, clinical and pathological profiles of …

Abstract p53 inactivation by disabling its function is a hallmark in lung carcinomas,
emphasizing the significance of restoring p53 function as an attractive therapeutic strategy …

Simple Summary Malignant pleural mesothelioma (MPM) is an aggressive tumor with
implacable prognosis. It commonly harbors loss-of-function mutations in BAP1, NF2 …

The TP53 gene is renowned as a tumor suppressor, playing a pivotal role in overseeing the
cell cycle, apoptosis, and maintaining genomic stability. Dysregulation of p53 often …

The objective of this study was to identify a kind of prognostic signature based on oxidative
stress-and anoikis-related genes (OARGs) for predicting the prognosis and immune …

Abstract p53 inactivation is a common feature in non-small cell lung cancer (NSCLC)
resulting in NSCLC malignant transformation. Targeting serine 392 phosphorylation to …

In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype
and ancestry. Emerging data suggest tumor mutation status is associated with germline …