Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia

VJM Verhoeven, PG Hysi, R Wojciechowski, Q Fan… - Nature …, 2013 - nature.com
Refractive error is the most common eye disorder worldwide and is a prominent cause of
blindness. Myopia affects over 30% of Western populations and up to 80% of Asians. The …

Development of refractive errors—what can we learn from inherited retinal dystrophies?

M Hendriks, VJM Verhoeven, GHS Buitendijk… - American Journal of …, 2017 - Elsevier
Purpose It is unknown which retinal cells are involved in the retina-to-sclera signaling
cascade causing myopia. As inherited retinal dystrophies (IRD) are characterized by …

Synaptic pathways that shape the excitatory drive in an OFF retinal ganglion cell

I Buldyrev, T Puthussery… - Journal of …, 2012 - journals.physiology.org
Different types of retinal ganglion cells represent distinct spatiotemporal filters that respond
selectively to specific features in the visual input. Much about the circuitry and synaptic …

Voltage-gated sodium channels contribute to the b-wave of the rodent electroretinogram by mediating input to rod bipolar cell GABAc receptors

BJ Smith, F Tremblay, PD Côté - Experimental eye research, 2013 - Elsevier
Voltage-gated sodium (Na v) channels are known to augment cone bipolar cell light
responses, increasing the electroretinogram (ERG) b-wave in response to stimulus strengths …

Dopamine modulates the off pathway in light‐adapted mouse retina

J Yang, J Pahng, GY Wang - Journal of neuroscience research, 2013 - Wiley Online Library
Abstract dl‐2‐Amino‐4‐phosphonobutyric acid (APB) is often used as a tool to block On
pathways in studies of interactions between On and Off pathways in retinas. APB is an …

Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina

AL Sladek, WB Thoreson - Frontiers in ophthalmology, 2023 - frontiersin.org
Introduction Light responses of rod photoreceptor cells traverse the retina through three
pathways. The primary pathway involves synapses from rods to ON-type rod bipolar cells …

Disinhibitory recruitment of NMDA receptor pathways in retina

S Sethuramanujam… - Journal of …, 2014 - journals.physiology.org
Glutamate release at bipolar to ganglion cell synapses activates NMDA and AMPA/kainic
acid (KA) ionotropic glutamate receptors. Their relative strength determines the output …

Submicromolar copper (II) ions stimulate transretinal signaling in the isolated retina from wild type but not from Cav2.3-deficient mice

JN Lüke, F Neumaier, S Alpdogan, J Hescheler… - BMC …, 2020 - Springer
Background So far, only indirect evidence exists for the pharmacoresistant R-type voltage-
gated Ca 2+ channel (VGCC) to be involved in transretinal signaling by triggering GABA …

Untersuchung der elektrophysiologischen Eigenschaften retinaler Ganglienzellen in der degenerierten Rattennetzhaut

S Hesse, F Müller, H Wagner, P Walter - 2021 - publications.rwth-aachen.de
Die vorliegende Arbeit zeigt den Einfluss der Photorezeptordegeneration auf die
Signalweiterleitung in der degenerierten Retina. Die folgenden Ergebnisse stellen sowohl …

Hyaluronan Does Not Affect Bupivacaine's Inhibitory Action on Voltage‐Gated Potassium Channel Activities in Bovine Articular Chondrocytes

W Hester, J Yang, GY Wang, S Liu… - Advances in …, 2012 - Wiley Online Library
Objectives. The objective of this paper is to determine if hyaluronan affects bupivacaine's
anesthetic function. Methods. Whole cell patch clamp recordings were performed on bovine …