The accumulation of protein aggregates is the hallmark of many neurodegenerative
diseases. The dysregulation of protein homeostasis (or proteostasis) caused by acute …

Nature has selected osmolytes to protect intracellular macromolecules exposed to
denaturing conditions and stabilize proteins. Osmolytes are small naturally occurring …

The potentiation of antibiotics is a promising strategy for combatting antibiotic-
resistant/tolerant bacteria. Herein, we report that a 5-min sublethal heat shock enhances the …

Introduction Previous observational studies have indicated that gut microbiota and
metabolites may contribute to heart failure and its risk factors. However, with the limitation of …

Understanding the structure, functionalities and biology of functional amyloids is an issue of
emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria …

Osmolytes are naturally occurring small molecules accumulated intracellularly to protect
organisms from various denaturing stresses. Similar to the two faces of a coin, several of …

The massive uptake of compatible osmolytes such as betaine, taurine, and myo-inositol is a
protective response shared by all eukaryotes exposed to hypertonic stress. Their …

Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …

Introduction Protein aggregation and deposition of uniformly arranged amyloid fibrils in the
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …

Osmolytes are small molecules that are exploited by cells as a protective system against
stress conditions. They favour compact protein states which makes them stabilize globular …