Mitochondrial dysfunction has been described as an early pathological mechanism
delineating the selective neurodegeneration that occurs in Huntington's disease (HD), a …

Huntington's disease (HD) is a devastating neurodegenerative disorder characterized by the
progressive development of involuntary choreiform movements, cognitive impairment …

Huntington's disease (HD) is the result of expression of a mutated Huntingtin protein (mtHtt),
and is associated with a variety of cellular dysfunctions including excessive mitochondrial …

There is no satisfactory treatment for Huntington's disease (HD), a hereditary
neurodegenerative disorder that produces chorea, dementia, and death. One potential …

In investigating the role of metal ions in the pathogenesis of Huntington's disease, we
examined the effects of clioquinol, a metal-binding compound currently in clinical trials for …

Glucose is the main circulating energy substrate for the adult brain. Owing to the high energy
demand of nerve cells, glucose is actively oxidized to produce ATP and has a synergistic …

The corresponding author requests retraction of the above referenced article due to
inappropriate manipulation and fabrication of data by the first author Dr. Antonio Valencia …

Introduction Tryptophan is a substrate for kynurenine pathway metabolism in the placenta.
We investigated if kynurenine metabolites change over gestation, if they are different …

Nicotinic acetylcholine receptors (nAChRs) are regarded as potential therapeutic targets to
control various neurodegenerative diseases. Owing to the relevance of cholinergic …

Huntington׳ s disease (HD) is a progressive and fatal neurodegenerative disorder caused by
a polyglutamine expansion in the gene encoding the protein huntingtin. The disease …