Chronic wounds

V Falanga, RR Isseroff, AM Soulika… - Nature Reviews …, 2022 - nature.com
Chronic wounds are characterized by their inability to heal within an expected time frame
and have emerged as an increasingly important clinical problem over the past several …

Wound healing: cellular mechanisms and pathological outcomes

HN Wilkinson, MJ Hardman - Open biology, 2020 - royalsocietypublishing.org
Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

Advanced bandages for diabetic wound healing

S Matoori, A Veves, DJ Mooney - Science translational medicine, 2021 - science.org
Current treatment options for foot ulcers, a serious and prevalent complication of diabetes,
remain nonspecific. In this Perspective, we present recent advances in understanding the …

Wound healing: a cellular perspective

M Rodrigues, N Kosaric, CA Bonham… - Physiological …, 2019 - journals.physiology.org
Wound healing is one of the most complex processes in the human body. It involves the
spatial and temporal synchronization of a variety of cell types with distinct roles in the …

Reactive Oxygen Species‐Scavenging Nanosystems in the Treatment of Diabetic Wounds

Y Xiong, X Chu, T Yu, S Knoedler… - Advanced …, 2023 - Wiley Online Library
Diabetic wounds are characterized by drug‐resistant bacterial infections, biofilm formation,
impaired angiogenesis and perfusion, and oxidative damage to the microenvironment …

[HTML][HTML] Mechanistic insight into diabetic wounds: Pathogenesis, molecular targets and treatment strategies to pace wound healing

S Patel, S Srivastava, MR Singh, D Singh - Biomedicine & …, 2019 - Elsevier
Wound management in diabetic patient is of an extreme clinical and social concern. The
delayed and impaired healing makes it more critical for research focus. The research on …

[HTML][HTML] The dynamics of the skin's immune system

AV Nguyen, AM Soulika - International journal of molecular sciences, 2019 - mdpi.com
The skin is a complex organ that has devised numerous strategies, such as physical,
chemical, and microbiological barriers, to protect the host from external insults. In addition …

[HTML][HTML] Single cell transcriptomic landscape of diabetic foot ulcers

G Theocharidis, BE Thomas, D Sarkar… - Nature …, 2022 - nature.com
Diabetic foot ulceration (DFU) is a devastating complication of diabetes whose pathogenesis
remains incompletely understood. Here, we profile 174,962 single cells from the foot …

[HTML][HTML] Deregulated immune cell recruitment orchestrated by FOXM1 impairs human diabetic wound healing

AP Sawaya, RC Stone, SR Brooks, I Pastar… - Nature …, 2020 - nature.com
Diabetic foot ulcers (DFUs) are a life-threatening disease that often result in lower limb
amputations and a shortened lifespan. However, molecular mechanisms contributing to the …

[HTML][HTML] Chronic diabetic wounds and their treatment with skin substitutes

J Holl, C Kowalewski, Z Zimek, P Fiedor, A Kaminski… - Cells, 2021 - mdpi.com
With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic,
hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The …