Nanopore-based fourth-generation DNA sequencing technology

Y Feng, Y Zhang, C Ying, D Wang… - Genomics, Proteomics …, 2015 - academic.oup.com
Nanopore-based sequencers, as the fourth-generation DNA sequencing technology, have
the potential to quickly and reliably sequence the entire human genome for less than 1000 …

The application of single molecule nanopore sensing for quantitative analysis

Y Wu, JJ Gooding - Chemical Society Reviews, 2022 - pubs.rsc.org
Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …

Nanopore analytics: sensing of single molecules

S Howorka, Z Siwy - Chemical Society Reviews, 2009 - pubs.rsc.org
In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …

Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances

S Xu, BZ Olenyuk, CT Okamoto… - Advanced drug delivery …, 2013 - Elsevier
Targeting of drugs and their carrier systems by using receptor-mediated endocytotic
pathways was in its nascent stages 25years ago. In the intervening years, an explosion of …

Synthetic multivalent ligands as probes of signal transduction

LL Kiessling, JE Gestwicki… - Angewandte Chemie …, 2006 - Wiley Online Library
Cell‐surface receptors acquire information from the extracellular environment and
coordinate intracellular responses. Many receptors do not operate as individual entities, but …

Protein detection by nanopores equipped with aptamers

D Rotem, L Jayasinghe, M Salichou… - Journal of the American …, 2012 - ACS Publications
Protein nanopores have been used as stochastic sensors for the detection of analytes that
range from small molecules to proteins. In this approach, individual analyte molecules …

Single-molecule site-specific detection of protein phosphorylation with a nanopore

CB Rosen, D Rodriguez-Larrea, H Bayley - Nature biotechnology, 2014 - nature.com
We demonstrate single-molecule, site-specific detection of protein phosphorylation with
protein nanopore technology. A model protein, thioredoxin, was phosphorylated at two …

Applications of biological pores in nanomedicine, sensing, and nanoelectronics

S Majd, EC Yusko, YN Billeh, MX Macrae… - Current opinion in …, 2010 - Elsevier
Biological protein pores and pore-forming peptides can generate a pathway for the flux of
ions and other charged or polar molecules across cellular membranes. In nature, these …

Design and creativity in synthesis of multivalent neoglycoconjugates

YM Chabre, R Roy - Advances in carbohydrate chemistry and biochemistry, 2010 - Elsevier
From the authors' opinion, this chapter constitutes a modest extension of the seminal and
inspiring contribution of Stowell and Lee on neoglycoconjugates published in this series [CP …

Multivalent glycoconjugate syntheses and applications using aromatic scaffolds

YM Chabre, R Roy - Chemical Society Reviews, 2013 - pubs.rsc.org
Glycan–protein interactions are of utmost importance in several biological phenomena.
Although the variety of carbohydrate residues in mammalian cells is limited to less than a …