Insights into amentoflavone: a natural multifunctional biflavonoid

X Xiong, N Tang, X Lai, J Zhang, W Wen, X Li… - Frontiers in …, 2021 - frontiersin.org
Amentoflavone is an active phenolic compound isolated from Selaginella tamariscina over
40 years. Amentoflavone has been extensively recorded as a molecule which displays …

Methodology-centered review of molecular modeling, simulation, and prediction of SARS-CoV-2

K Gao, R Wang, J Chen, L Cheng, J Frishcosy… - Chemical …, 2022 - ACS Publications
Despite tremendous efforts in the past two years, our understanding of severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), virus–host interactions, immune …

The inhibitory effects of plant derivate polyphenols on the main protease of SARS coronavirus 2 and their structure–activity relationship

TTH Nguyen, JH Jung, MK Kim, S Lim, JM Choi… - Molecules, 2021 - mdpi.com
The main protease (Mpro) is a major protease having an important role in viral replication of
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus …

Potent toxic effects of Taroxaz-104 on the replication of SARS-CoV-2 particles

AM Rabie - Chemico-Biological Interactions, 2021 - Elsevier
Abstract Polyphenolics and 1, 3, 4-oxadiazoles are two of the most potent bioactive classes
of compounds in medicinal chemistry, since both are known for their diverse …

Systems pharmacology-based drug discovery and active mechanism of natural products for coronavirus pneumonia (COVID-19): An example using flavonoids

B Wang, Y Ding, P Zhao, W Li, M Li, J Zhu… - Computers in Biology and …, 2022 - Elsevier
Background Recently, the value of natural products has been extensively considered
because these resources can potentially be applied to prevent and treat coronavirus …

Drug design strategies for the treatment of viral disease. Plant phenolic compounds and their derivatives

M Kowalczyk, A Golonko, R Świsłocka… - Frontiers in …, 2021 - frontiersin.org
The coronavirus pandemic (SARS CoV-2) that has existed for over a year, constantly forces
scientists to search for drugs against this virus. In silico research and selected experimental …

Nanotechnology applications of flavonoids for viral diseases

K Jannat, AK Paul, TA Bondhon, A Hasan, M Nawaz… - Pharmaceutics, 2021 - mdpi.com
Recent years have witnessed the emergence of several viral diseases, including various
zoonotic diseases such as the current pandemic caused by the Severe Acute Respiratory …

Exploring the inhibitory potential of Saussurea costus and Saussurea involucrata phytoconstituents against the Spike glycoprotein receptor binding domain of SARS …

S Houchi, Z Messasma - Journal of Molecular Structure, 2022 - Elsevier
Abstract The B. 1.617. 2 Delta variant is considered to be the most infectious of all SARS-
CoV2 variants. Here, an attempt has been made through in-silico screening of 55 bioactive …

Effectiveness of Natural Antioxidants against SARS-CoV-2? Insights from the In-Silico World

MF Rehman, S Akhter, AI Batool, Z Selamoglu… - Antibiotics, 2021 - mdpi.com
The SARS CoV-2 pandemic has affected millions of people around the globe. Despite many
efforts to find some effective medicines against SARS CoV-2, no established therapeutics …

Discovery of Taroxaz-104: The first potent antidote of SARS-CoV-2 VOC-202012/01 strain

AM Rabie - Journal of Molecular Structure, 2021 - Elsevier
Polyhydroxyphenols and nitrogenous heterocyclics are two of the most powerful active
species of molecules in pharmaceutical chemistry, as each of them is renowned for its …