[HTML][HTML] Acid-sensing ion channels: focus on physiological and some pathological roles in the brain

M Storozhuk, A Cherninskyi, O Maximyuk… - Current …, 2021 - ncbi.nlm.nih.gov
Acid-sensing ion channels (ASICs) are Na+-permeable ion channels activated by protons
and predominantly expressed in the nervous system. ASICs act as pH sensors leading to …

Acid-sensing ion channels and mechanosensation

N Ruan, J Tribble, AM Peterson, Q Jiang… - International journal of …, 2021 - mdpi.com
Acid-sensing ion channels (ASICs) are mainly proton-gated cation channels that are
activated by pH drops and nonproton ligands. They are part of the degenerin/epithelial …

The role of zinc in modulating acid-sensing ion channel function

AW Sun, MH Wu, M Vijayalingam, MJ Wacker, XP Chu - Biomolecules, 2023 - mdpi.com
Acid-sensing ion channels (ASICs) are proton-gated, voltage-independent sodium channels
widely expressed throughout the central and peripheral nervous systems. They are involved …

Mice lacking acid-sensing ion channel 2 in the medial prefrontal cortex exhibit social dominance

B Lin, Z Jin, G Park, Q Ge, K Singh, WG Ryan V… - Science …, 2024 - science.org
Social dominance is essential for maintaining a stable society and has both positive and
negative impacts on social animals, including humans. However, the regulatory …

Carbonic anhydrase 4 disruption decreases synaptic and behavioral adaptations induced by cocaine withdrawal

SC Gupta, A Ghobbeh, RJ Taugher-Hebl, R Fan… - Science …, 2022 - science.org
Cocaine use followed by withdrawal induces synaptic changes in nucleus accumbens
(NAc), which are thought to underlie subsequent drug-seeking behaviors and relapse …

Synaptic signals mediated by protons and acid‐sensing ion channels

OD Uchitel, C Gonzalez Inchauspe, C Weissmann - Synapse, 2019 - Wiley Online Library
Extracellular pH changes may constitute significant signals for neuronal communication.
During synaptic transmission, changes in pH in the synaptic cleft take place. Its role in the …

Triggering of major brain disorders by protons and ATP: The role of ASICs and P2X receptors

A Cherninskyi, M Storozhuk, O Maximyuk, V Kulyk… - Neuroscience …, 2023 - Springer
Adenosine triphosphate (ATP) is well-known as a universal source of energy in living cells.
Less known is that this molecule has a variety of important signaling functions: it activates a …

Interactive role of acid sensing ion channels and glutamatergic system in opioid dependence

F Alasmari, DB Sari, H Alhaddad, SS Al-Rejaie… - Neuroscience & …, 2022 - Elsevier
Dysregulation in glutamatergic receptors and transporters has been found to mediate drugs
of abuse, including morphine. Among glutamate receptors, ionotropic glutamate receptors …

Acid-sensing ion channel 2: Function and modulation

A Sivils, F Yang, JQ Wang, XP Chu - Membranes, 2022 - mdpi.com
Acid-sensing ion channels (ASICs) have an important influence on human physiology and
pathology. They are members of the degenerin/epithelial sodium channel family. Four genes …

Role of ASIC1a in normal and pathological synaptic plasticity

D Mango, R Nisticò - Reviews of physiology, biochemistry and …, 2020 - Springer
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel
superfamily, are broadly distributed in the mammalian nervous system where they play …