Secondary hyperparathyroidism develops in CKD due to a combination of vitamin D
deficiency, hypocalcemia, and hyperphosphatemia, and it exists in nearly all patients at the …

Vascular calcification contributes to the high risk of cardiovascular mortality in chronic kidney
disease (CKD) patients. Dysregulation of calcium (Ca) and phosphate (P) metabolism is …

Extracellular phosphate regulates its own renal excretion by eliciting concentration-
dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing …

Introduction: Chronic kidney disease as a public health problem. Chronic kidney disease is
a worldwide public health problem. In the United States, there is a rising incidence and …

Elevated serum phosphorus is a predictable accompaniment of end-stage renal disease
(ESRD) in the absence of dietary phosphate restriction or supplemental phosphate binders …

Disturbances in mineral and bone metabolism are common in patients with CKD. A large
body of evidence indicates that these derangements are associated with increased mortality …

Masafumi Fukagawa, 1 Keitaro Yokoyama, 1 Fumihiko Koiwa, 1 Masatomo Taniguchi, 1
Tetsuo Shoji, 1 Junichiro James Kazama, 1 Hirotaka Komaba, 1 Ryoichi Ando, 1 Takatoshi …

Mineral bone disease (MBD) is a common complication of chronic kidney disease (CKD)
characterized by disruption of normal mineral homeostasis within the body. One or more of …

Within the normal range, higher serum phosphate concentrations are associated with
cardiovascular events and mortality in individuals with chronic kidney disease (CKD) and in …

In mammals, phosphate balance is maintained by influx and efflux via the intestines,
kidneys, bone, and soft tissue, which involves multiple sodium/phosphate (Na+/Pi) …