The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

Depression has been widely accepted as a major psychiatric disease affecting nearly 350
million people worldwide. Research focus is now shifting from studying the extrinsic and …

Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its
function in the central nervous system is unknown. Roles in development, sexual …

Microglia cells are the brain counterpart of macrophages and function as the first defense in
the brain. Although they are neuroprotective in the young brain, microglia cells may be …

The SAM strains, a group of related inbred strains consisting of senescence-prone inbred
strains (SAMP) and senescence-resistant inbred strains (SAMR), have been successfully …

Subarachnoid hemorrhage represents a serious disease with high mortality and morbidity.
Two important areas are becoming the central research interest of subarachnoid …

Neuroinflammatory changes, characterized by an increase in microglial activation and often
accompanied by upregulation of inflammatory cytokines like interleukin-1β (IL-1β), are …

Formulated as a group effort of the stroke community, the transforming concept of the
neurovascular unit (NVU) depicts the structural and functional relationship between brain …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative condition that has
devastating effects on individuals, often resulting in dementia. AD is primarily defined by the …