Tumor microenvironment is a complex system that contains multiple cells and cytokines.
Among the multiple immune cells, macrophage is particularly abundant and plays an …

Abstract The Transforming Growth Factor-beta (TGFβ) pathway mediates a broad spectrum
of cellular processes and is involved in several diseases, including cancer. TGFβ has a dual …

Lung cancer is considered one of the most frequent causes of cancer-related death
worldwide and Non-Small Cell Lung Cancer (NSCLC) accounts for 80% of all lung cancer …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …

Epithelial to mesenchymal transition (EMT) is a progression of cellular plasticity critical for
development, differentiation, cancer cells migration and tumor metastasis. As a well-studied …

Signals from the transforming growth factor-β (TGF-β) superfamily mediate a broad spectrum
of cellular processes and are deregulated in many diseases, including cancer. TGF-β …

Purpose: Lung fibrosis is a major side effect experienced by patients after lung cancer
radiotherapy. However, effective protection strategies and underlying treatment targets …

Serpin family E member 1 (SERPINE1), a serine proteinase inhibitor, serves as an important
regulator of extra-cellular matrix remodeling. Emerging evidence suggests that SERPINE1 …

Lung cancer is one of the most devastating types of malignant tumors, and a prime example
of a chemical carcinogenesis-driven tumor entity. Lung cancer progression does not only …

Abstract Sorafenib (BAY 43–9006) was developed as a multi-kinase inhibitor to treat
advanced renal cell, hepatocellular, and thyroid cancers. The cytotoxic effect of sorafenib on …