Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Uterine fibroids (UFs), also known as leiomyomas, are benign tumors of the myometrium
affecting over 70% of women worldwide, particularly women of color. Although benign, UFs …

Uterine leiomyoma is the most common tumor of the female reproductive system and
originates from a single transformed myometrial smooth muscle cell. Despite the immense …

Background Uterine fibroids are highly prevalent, collagen‐rich, mechanically stiff, fibrotic
tumors for which new therapeutic options are needed. Increased extracellular matrix (ECM) …

Postpartum depression (PPD) is a leading cause of morbidity and mortality among women.
Clinically, the administration and withdrawal of supraphysiologic estradiol and progesterone …

Objective To test whether mechanical substrate stiffness would influence progesterone
receptor B (PRB) signaling in fibroid cells. Uterine fibroids feature an excessive extracellular …

Fibrillar collagen deposition, stiffness and downstream signalling support the development
of leiomyomas (LMs), common benign mesenchymal tumours of the uterus, and are …

Uterine fibroid or leiomyoma is the most common benign uterus tumor. The tumor is primarily
composed of smooth muscle (fibroid) cells, myofibroblast, and a significant amount of …

Adenomyosis remains an enigmatic disease in the clinical and research communities. The
high prevalence, diversity of morphological and symptomatic presentations, array of …

Mechanical forces collaborate across length scales to coordinate cell fate during
development and the dynamic homeostasis of adult tissues. Similarly, steroid hormones …