Metastasis is the main cause of cancer-related mortality. Although the actual process of
metastasis remains largely elusive, epithelial-mesenchymal transition (EMT) has been …

Cutaneous melanoma is a common cancer and cases have steadily increased since the mid
70s. For some patients, early diagnosis and surgical removal of melanomas is lifesaving …

The interplay between apoptotic cancer cells and the tumor microenvironment modulates
cancer progression and metastasis. Cancer-associated fibroblasts (CAFs) play a crucial role …

CCN4 (cellular communication network factor 4), a highly conserved, secreted cysteine-rich
matricellular protein is emerging as a key player in the development and progression of …

Recent advancements highlight the intricate interplay between the extracellular matrix
(ECM) and immune responses, notably in respiratory diseases such as asthma and Chronic …

Metastatic melanoma is a complex and deadly disease. Due to its complexity, the
development of novel therapeutic strategies to inhibit metastatic melanoma remains an …

The crosstalk between tumor cells and the tumor microenvironment (TME), triggers a variety
of critical signaling pathways and promotes the malignant progression of cancer. The …

Background: The migration, proliferation and apoptosis of vascular smooth muscle cells
(VSMCs) are critical for plaque stability. WNT-inducible signalling pathway protein-1 …

Background and aims Novel pro-and anti-inflammatory adipocytokines affect inflammation,
energy metabolism, and insulin signaling. However, their role in acute coronary syndrome …

Background: Metastatic prostate cancer (PCa) predicts a poor prognosis and lower
likelihood of survival. Osteoblasts (OBs) are known to be responsible for the synthesis and …