Mast cells (MC) are widely distributed throughout the body and are common at mucosal
surfaces, a major host–environment interface. MC are functionally and phenotypically …

Lysosomes were once considered the end point of endocytosis, simply used for
macromolecule degradation. They are now recognized to be dynamic organelles, able to …

Platelets play a central role in the arrest of bleeding after damage to a blood vessel and in
the development of thrombosis. Platelets rapidly respond after interaction with sub …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Trans-acting genetic variants have a substantial, albeit poorly characterized, role in the
heritable determination of gene expression. Using paired purified primary monocytes and B …

Natural killer (NK) cell‐mediated cytotoxicity is governed by the formation of a lytic immune
synapse in discrete regulated steps, which give rise to an extensive array of cellular …

Natural killer (NK) cells form a subset of lymphocytes that play a key role in immuno-
surveillance and host defense against cancer and viral infections. They recognize stressed …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

Rab27, a member of the small GTPase Rab family, is widely conserved in metazoan, and
two Rab27 isoforms, Rab27A and Rab27B, are present in vertebrates. Rab27A was the first …

Unique functions of specialised cells such as those of the immune and haemostasis
systems, skin, blood vessels, lung, and bone require specialised compartments, collectively …