Currently, more than 170 modifications have been identified on RNA. Among these RNA
modifications, various methylations account for two-thirds of total cases and exist on almost …

Interferon-stimulated gene (ISG) products take on a number of diverse roles. Collectively,
they are highly effective at resisting and controlling pathogens. In this review, we begin by …

RNA transcripts are bound and regulated by RNA-binding proteins (RBPs). Current methods
for identifying in vivo targets of an RBP are imperfect and not amenable to examining small …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

As central components of RNA silencing, small RNAs play diverse and important roles in
many biological processes in eukaryotes. Aberrant reduction or elevation in the levels of …

RNA editing is a cellular process that precisely alters nucleotide sequences, thus regulating
gene expression and generating protein diversity. Over 60% of human transcripts undergo …

Chronic inflammation has long been recognized as a risk factor for many human cancers.
One mechanistic link between inflammation and cancer involves the generation of nitric …

RNA editing and splicing are the two major processes that dynamically regulate human
transcriptome diversity. Despite growing evidence of crosstalk between RNA editing …

As an alternative to DNA mutagenesis, RNA mutagenesis can potentially become a powerful
gene-regulation method for fundamental research and applied life sciences. Adenosine-to …

The progressive maturation and functional plasticity of the nervous system in health and
disease involve a dynamic interplay between the transcriptome and the environment. There …