Cytokines regulate a broad range of inflammatory processes that are implicated in the
pathogenesis of rheumatoid arthritis. In rheumatoid joints, it is well known that an imbalance …

The interferon signature in autoimmune diseases : Current Opinion in Rheumatology The
interferon signature in autoimmune diseases : Current Opinion in Rheumatology Log in or …

Tumor necrosis factor (TNF) is a key driver of several inflammatory diseases, such as
rheumatoid arthritis, inflammatory bowel disease, and psoriasis, in which affected tissues …

We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …

Objective To characterise activation of the type I interferon (IFN) pathway in patients with
systemic lupus erythematosus (SLE), dermatomyositis (DM), polymyositis (PM), rheumatoid …

Background Plasmacytoid dendritic cells have been implicated in the pathogenesis of
systemic sclerosis through mechanisms beyond the previously suggested production of type …

Abstract Type I interferons (IFN-Is) are a group of molecules with pleiotropic effects on the
immune system forming a crucial link between innate and adaptive immune responses …

Signaling via the methylation of lysine residues in proteins has been linked to diverse
biological and disease processes, yet the catalytic activity and substrate specificity of many …

There is increasing scientific and clinical interest in elucidating the biology of type I
Interferons, which began approximately 60 years ago with the concept of “viral interference” …

Type I interferons (IFN) can have dual and opposing roles in immunity, with effects that are
beneficial or detrimental to the individual depending on whether IFN pathway activation is …