Pyronaridine was synthesized in 1970 at the Institute of Chinese Parasitic Disease and has
been used in China for over 30 years for the treatment of malaria. Pyronaridine has high …

Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the
WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based …

There are currently relatively few small-molecule antiviral drugs that are either approved or
emergency-approved for use against severe acute respiratory coronavirus 2 (SARS-CoV-2) …

This historical review covers antimalarials developed in China, which include artemisinin,
artemether, artesunate, and dihydroartemisinin, as well as other synthetic drugs such as …

Recent outbreaks of the Ebola virus (EBOV) have focused attention on the dire need for
antivirals to treat these patients. We identified pyronaridine tetraphosphate as a potential …

Antimalarial drug resistance in the Plasmodium falciparum parasite poses a constant
challenge for drug development. To mitigate this risk, new antimalarial medicines should be …

Neuroblastoma (NB) is the second leading extracranial solid tumor of early childhood with
about two-thirds of cases presenting before the age of 5, and accounts for roughly 15 …

The recent outbreaks of the Ebola virus (EBOV) in Africa have brought global visibility to the
shortage of available therapeutic options to treat patients infected with this or closely related …

Among the most central aspects of the drug-development process is estimation of drug
levels in biological systems, which is an integral part of preclinical and clinical studies. Once …

An improved high-performance liquid chromatography method using a diisopropyl-C14
reversed-phase column (Zorbax Bonus-RP column) and a liquid–liquid extraction technique …