Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …

Bacterial transition metal homoeostasis or simply 'metallostasis' describes the process by
which cells control the intracellular availability of functionally required metal cofactors, from …

Transcription factors (TFs) modulate gene expression by regulating the accessibility of
promoter DNA to RNA polymerases (RNAPs) in bacteria. The MerR family TFs are a large …

Nickel is an essential metal for a number of bacterial species that have developed systems
for acquiring, delivering, and incorporating the metal into target enzymes and controlling the …

The MerR family of transcriptional regulators includes a variety of bacterial cytoplasmic
proteins that respond to a wide range of signals, including toxins, metal ions, and …

Nickel is an essential micronutrient for a large number of living organisms, but it is also a
toxic metal ion when it accumulates beyond the sustainable level as it may result if and …

Nickel is essential for the survival of many pathogenic bacteria. E. coli and H. pylori require
nickel for [NiFe]-hydrogenases. H. pylori also requires nickel for urease. At high …

Background Haemophilus influenzae colonizes the nasopharynx as a commensal. Strain-
specific factors allow some strains to migrate to particular anatomical niches, such as the …

Conjugative transfer through type IV secretion multiprotein complexes is the most important
means of spreading antimicrobial resistance. Plasmid pIP501, frequently found in clinical …

3.1 Introduction as far as we know, nickel is non-essential for humans; however,
microorganisms, plants, and some animal species require nickel for survival. 1–3 these …