The initiation of DNA replication represents a committing step to cell proliferation.
Appropriate replication onset depends on multiprotein complexes that help properly …

The tree of life shows the relationship between all organisms based on their common
ancestry. Until 1977, it comprised two major branches: prokaryotes and eukaryotes. Work by …

DNA replication is essential for all life forms. Although the process is fundamentally
conserved in the three domains of life, bioinformatic, biochemical, structural, and genetic …

Eukaryotic chromosomal DNA replication is controlled by a highly ordered series of steps
involving multiple proteins at replication origins. The eukaryotic GINS complex is essential …

Archaea, the third domain of life, are interesting organisms to study from the aspects of
molecular and evolutionary biology. Archaeal cells have a unicellular ultrastructure without a …

In eukaryotic DNA replication initiation, hexameric MCM (mini-chromosome maintenance)
unwinds the template double-stranded DNA to form the replication fork. MCM is activated by …

In eukaryotes, the replicative DNA helicase 'core'is the minichromosome maintenance
(Mcm) complex (MCM), forming a heterohexameric complex consisting of six subunits …

Genomic DNA replication requires replisome assembly. We show here the molecular
mechanism by which CMG (GAN–MCM–GINS)-like helicase cooperates with the family D …

The precise and timely duplication of the genome is essential for cellular life. It is achieved
by DNA replication, a complex process that is conserved among the three domains of life …

Bladder cancer (BC) is one of the most prevalent cancers in the urinary tract, with high
recurrence and fatality rates. Research indicates that go-ichi-ni-san complex subunit 1 …