Folk wisdom has long suggested that stressful events take a toll on health. The field of
psychoneuroimmunology (PNI) is now providing key mechanistic evidence about the ways …

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled
receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures …

Studies in mammalian skin have shown expression of the genes for corticotropin‐releasing
hormone (CRH) and the related urocortin peptide, with subsequent production of the …

Corticotropin-releasing hormone (CRH) exerts an anti-inflammatory effect indirectly, via
cortisole production, and a proinflammatory effect directly on immune cells. The aim of the …

[Frontiers in Bioscience 12, 1615-1628, January 1, 2007] 1615 Corticotropin-releasing hormone
and the blood-brain-barrier Theoha Page 1 [Frontiers in Bioscience 12, 1615-1628, January 1 …

Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been
found to bind with high affinity to CRF receptors. The present study investigated urocortin …

Opioid-containing leukocytes can counteract inflammatory hyperalgesia. Under stress or
after local injection of corticotropin releasing factor (CRF), opioid peptides are released from …

Immunological and cellular stress signals trigger the release of corticotropin-releasing
hormone (CRH) from the spleen, thymus and inflamed tissue. In vivo and in vitro studies …

Throughout life organisms are challenged with various physiological and psychological
stressors, and the ability to handle these stressors can have profound effects on the overall …