Genetic variations resulting in a change of amino acid sequence can have a dramatic effect
on stability, hydrogen bond network, conformational dynamics, activity and many other …

Carbon-oxygen (CH··· O) hydrogen bonding represents an unusual category of molecular
interactions first documented in biological structures over 4 decades ago. Although CH··· O …

Cardiac involvement has a profound effect on the prognosis of patients with systemic
amyloidosis. Therapeutic methods for suppressing the production of causative proteins have …

Transthyretin is a highly conserved homotetrameric protein, mainly synthetized by the liver
and the choroid plexus of brain. The carrier role of TTR is well-known; however, many other …

Posttranslational modification is an evolutionarily conserved mechanism for regulating
protein activity, binding affinity, and stability. Compared with established posttranslational …

Neutron protein crystallography is a powerful tool for investigating protein chemistry
because it directly locates hydrogen atom positions in a protein structure. The visibility of …

Sequence-defined peptoids, or N-substituted glycines, are an attractive class of bioispired
polymer due to their biostability and efficient synthesis. However, the de novo design of …

Transthyretin (TTR) amyloidoses are systemic diseases associated with TTR aggregation
and extracellular deposition in tissues as amyloid. The most frequent and severe forms of …

A human molecular chaperone protein, DnaJ heat shock protein family (Hsp40) member B6
(DNAJB6), efficiently inhibits amyloid aggregation. This inhibition depends on a unique motif …

Transthyretin (TTR) is a thyroid hormone-binding protein which transports thyroxine from the
bloodstream to the brain. The structural stability of TTR in tetrameric form is crucial for …