Antiviral activity exerted by natural products against human viruses
M Musarra-Pizzo, R Pennisi, I Ben-Amor, G Mandalari… - Viruses, 2021 - mdpi.com
Viral infections are responsible for several chronic and acute diseases in both humans and
animals. Despite the incredible progress in human medicine, several viral diseases, such as …
animals. Despite the incredible progress in human medicine, several viral diseases, such as …
Target identification for small bioactive molecules: finding the needle in the haystack
S Ziegler, V Pries, C Hedberg… - Angewandte Chemie …, 2013 - Wiley Online Library
Identification and confirmation of bioactive small‐molecule targets is a crucial, often decisive
step both in academic and pharmaceutical research. Through the development and …
step both in academic and pharmaceutical research. Through the development and …
ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C
Cholesterol activates the master growth regulator, mTORC1 kinase, by promoting its
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …
recruitment to the surface of lysosomes by the Rag guanosine triphosphatases (GTPases) …
A four-step cycle driven by PI (4) P hydrolysis directs sterol/PI (4) P exchange by the ER-Golgi tether OSBP
Several proteins at endoplasmic reticulum (ER)-Golgi membrane contact sites contain a PH
domain that interacts with the Golgi phosphoinositide PI (4) P, a FFAT motif that interacts …
domain that interacts with the Golgi phosphoinositide PI (4) P, a FFAT motif that interacts …
NPC1-mTORC1 signaling couples cholesterol sensing to organelle homeostasis and is a targetable pathway in Niemann-Pick type C
Lysosomes promote cellular homeostasis through macromolecular hydrolysis within their
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
lumen and metabolic signaling by the mTORC1 kinase on their limiting membranes. Both …
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways
Chaperones are abundant cellular proteins that promote the folding and function of their
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
substrate proteins (clients). In vivo, chaperones also associate with a large and diverse set …
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol
H Kemmoku, K Takahashi, K Mukai, T Mori… - Nature …, 2024 - nature.com
Stimulator of interferon genes (STING) is critical for the type I interferon response to
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …
pathogen-or self-derived DNA in the cytosol. STING may function as a scaffold to activate …
Sterol transfer, PI 4P consumption, and control of membrane lipid order by endogenous OSBP
The network of proteins that orchestrate the distribution of cholesterol among cellular
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …
organelles is not fully characterized. We previously proposed that oxysterol‐binding protein …
Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins
The internal organization of eukaryotic cells into functionally specialized, membrane-
delimited organelles of unique composition implies a need for active, regulated lipid …
delimited organelles of unique composition implies a need for active, regulated lipid …
Regulation of cellular cholesterol distribution via non-vesicular lipid transport at ER-Golgi contact sites
Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …