Pyronaridine (PYR) is an erythrocytic schizonticide with a potent antimalarial activity against
multidrug‐resistant Plasmodium. The drug is used in combination with artesunate for the …

Pyronaridine-artesunate was recently strongly recommended in the 2022 update of the
WHO Guidelines for the Treatment of Malaria, becoming the newest artemisinin-based …

Our previous study identified 52 antiplasmodial peptaibols isolated from fungi. To
understand their antiplasmodial mechanism of action, we conducted phenotypic assays …

Background Malaria is one of the leading causes of death worldwide caused by parasites of
the genus Plasmodium. The reduced efficacy of the mainstay antimalarial drugs due to the …

An appropriate pH maintenance within a membrane-enclosed organelle is vital for the
occurrence of biological processes. Artemisinin (ART), a potent antimalarial drug has been …

The hemoglobin uptake and transport by the malaria parasite, Plasmodium falciparum are
preferable targets for antimalarial drug development. There is a need for alternative …

The reduced efficacy of the mainstay antimalarial drugs due to the widespread of
drugresistant Plasmodium falciparum has necessitated efforts to discover new antimalarial …

Plasmodium knowlesi shows a predilection towards human reticulocytes that have the Duffy
blood group antigens required for malaria parasite invasion. Low concentration of …

Pyrogallol has a capability of generating free radicals like other antimalarial drugs such as
artemisinin, which is thought to inhibit the proton pump located in the membrane of the …

The acidic pH of the digestive vacuole (DV) of P. falciparum is thought to play a major role in
the mechanisms of digestion of host erythrocyte hemoglobin, detoxification of heme, and …