Macrophages become activated initiating innate immune responses. Depending on the
signals, macrophages obtain an array of activation phenotypes, described by the broad …

Protein kinase B (Akt), similar to many other protein kinases, is at the crossroads of cell
death and survival, playing a pivotal role in multiple interconnected cell signaling …

The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of
macrophages, which may impact the development of atherosclerosis. Changes in Akt …

Smooth muscle cells (SMCs) play a key role in atherogenesis. However, mechanisms
regulating expansion and fate of pre-existing SMCs in atherosclerotic plaques remain poorly …

Macrophage apoptosis and the ability of macrophages to clean up dead cells, a process
called efferocytosis, are crucial determinants of atherosclerosis lesion progression and …

Atherosclerosis, the major cause of cardiovascular disease, is a chronic inflammatory
disease characterized by the accumulation of lipids and inflammatory cells in the artery wall …

Atherosclerosis is a chronic progressive inflammation course, which could induce life‐
threatening diseases such as stroke and myocardial infarction. Optimal medical treatments …

There is a large body of evidence that cellular metabolism governs inflammation, and that
inflammation contributes to the progression of atherosclerosis. However, whether …

Background: Cross-talk between sterol metabolism and inflammatory pathways has been
demonstrated to significantly affect the development of atherosclerosis. Cholesterol …

Non‐alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic
syndrome, being a common comorbidity of type 2 diabetes and with important links to …