Recent studies of the pathophysiology of migraine provide evidence that the headache
phase is associated with multiple physiologic actions. These actions include the release of …

Current theories propose that the primary dysfunction in migraine occurs within the CNS and
that this evokes changes in blood vessels within pain-producing intracranial meningeal …

Migraine headache pathophysiology involves trigeminovascular system activation,
calcitonin gene-related peptide (CGRP) release, and dysfunctional nociceptive …

The trigeminovascular system plays a key role in the pathophysiology of migraine. The
activation of the trigeminovascular system causes release of various neurotransmitters and …

The cerebrovascular receptor (s) that mediates 5‐hydroxytryptamine (5‐HT)‐induced
vasoconstriction in human cerebral arteries (HCA) has proven difficult to characterize, yet …

Objective To review and highlight current literature on emerging acute migraine treatments,
focusing on CGRP receptor antagonists, gepants, and 5‐HT1F receptor agonists (ditans) …

Vasodilatation in the dura mater has been implicated in migraine pathogenesis. Anti‐
migraine triptan drugs block vasodilatation by binding to 5‐HT1B/1D receptors localized on …

In this randomized, double-blind, placebo-controlled, parallel-group study, patients received
a single 50-mg oral dose of a 5-HT1D agonist, PNU-142633 (n= 34), or matching placebo …

Anti-migraine triptan drugs are 5-HT 1B/1D receptor agonists which are thought to block the
neurotransmitter/neuropeptide release from sensory nerve terminals and directly constrict …

Primary headaches such as migraine are among the most prevalent neurological disorders,
affecting up to one-fifth of the adult population. The scientific work in the last decade has …