Past, present and future of the Biginelli reaction: a critical perspective.

JS Sandhu - ARKIVOC: Online Journal of Organic …, 2012 - search.ebscohost.com
This review covers up to 2010 and some available references of 2011 of synthetic advances
in the Biginelli reaction, including recent mechanistic advances, new building blocks, new …

Metal-free multicomponent reactions: a benign access to monocyclic six-membered N-heterocycles

KN Singh - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
The advent of multicomponent reactions in the synthesis of heterocycles and their ever
burgeoning applications in drug development, materials chemistry, and catalysis, have …

Brønsted Base-Catalyzed One-Pot Three-Component Biginelli-Type Reaction: An Efficient Synthesis of 4,5,6-Triaryl-3,4-dihydropyrimidin-2(1H)-one and Mechanistic …

ZL Shen, XP Xu, SJ Ji - The Journal of Organic Chemistry, 2010 - ACS Publications
An efficient one-pot synthesis of 4, 5, 6-triaryl-3, 4-dihydropyrimidin-2 (1 H)-ones via a three-
component Biginelli-type condensation of aldehyde, 2-phenylacetophenone, and …

A chemical placebo: NaCl as an effective, cheapest, non-acidic and greener catalyst for Biginelli-type 3,4-dihydropyrimidin-2(1H)-ones (-thiones) synthesis

MA Kolosov, VD Orlov, DA Beloborodov… - Molecular diversity, 2009 - Springer
Despite prior reports of several really effective catalytic and non-catalytic approaches
towards Biginelli's 3, 4-dihydropyrimidin-2 (1 H)-ones, an overwhelming number of new …

Synthesis of dihydropyrimidinones and thiones by multicomponent reactions: strategies beyond the classical Biginelli reaction

JP Wan, Y Liu - Synthesis, 2010 - thieme-connect.com
The three-component Biginelli reaction for the synthesis of dihydropyrimidinone and
corresponding dihydropyrimidinethiones (DHPMs) has been known for more than a century …

The cyanamide moiety, synthesis and reactivity

MH Larraufie, G Maestri, M Malacria, C Ollivier… - …, 2012 - thieme-connect.com
The cyanamide moiety provides many opportunities as a building block for the synthesis of
nitrogen-containing heterocycles. This review discusses the reported methods for the …

Biginelli condensation: synthesis and structure diversification of 3, 4-dihydropyrimidin-2 (1H)-one derivatives

K Singh, K Singh - Advances in heterocyclic chemistry, 2012 - Elsevier
The realization of therapeutic potential of 3, 4-dihydropyrimidin-2 (1H)-ones (DHPMs) and
their structural as well as receptor bound conformational similarity with potent cardiovascular …

Enantiospecific Recognition at the A2B Adenosine Receptor by Alkyl 2-Cyanoimino-4-substituted-6-methyl-1,2,3,4-tetrahydropyrimidine-5-carboxylates

C Carbajales, J Azuaje, A Oliveira… - Journal of medicinal …, 2017 - ACS Publications
A novel family of structurally simple, potent, and selective nonxanthine A2BAR ligands was
identified, and its antagonistic behavior confirmed through functional experiments. The …

Environmentally Benign One-Pot Synthesis of Cyanamides from Dithiocarbamates Using I2 and H2O2

L Jamir, UB Sinha, J Nath, BK Patel - Synthetic Communications, 2012 - Taylor & Francis
Full article: Environmentally Benign One-Pot Synthesis of Cyanamides from
Dithiocarbamates Using I2 and H2O2 Skip to Main Content Taylor and Francis Online …

Synthesis, crystal structure and Hirshfeld surface analysis of the 1-(3, 6-dihydropyrimidin-2-yl) urea salt structurally related to dihydropyrimidinon-2-ylurea-type RNA …

A Salinas-Hernández, GE Delgado… - Journal of Molecular …, 2022 - Elsevier
The postmulticomponent synthesis and crystal structure of 1-(3, 6-dihydropyrimidin-2-yl)
urea salt, 5-(ethoxycarbonyl)-4-methyl-6-phenyl-2-ureido-3, 6-dihydropyrimidin-1-ium …