Adaptive immune responses play critical roles in viral clearance and protection against re‐
infection, and SARS‐CoV‐2 is no exception. What is exceptional is the rapid …

Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …

The coronavirus spike glycoprotein, located on the virion surface, is the key mediator of cell
entry and the focus for development of protective antibodies and vaccines. Structural studies …

Dysregulated immune responses against the SARS-CoV-2 virus are instrumental in severe
COVID-19. However, the immune signatures associated with immunopathology are poorly …

Generating a broadly protective influenza vaccine is critical to global health. Understanding
how immune memory influences influenza immunity is central to this goal. We undertook an …

INTRODUCTION The ultimate goal of de novo protein design is to create proteins endowed
with new biological functions. From a structural perspective, this remains a challenge …

Immunoglobulins (Ig) play an important role in the immune system both when expressed as
antigen receptors on the cell surface of B cells and as antibodies secreted into extracellular …

Pathogenic H7N9 avian influenza viruses continue to represent a public health concern, and
several candidate vaccines are currently being developed. It is vital to assess if protective …

The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high
levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which …

Human broadly neutralizing antibodies (bnAbs) targeting the hemagglutinin stalk of group 1
influenza A viruses (IAVs) are biased for IGHV1-69 alleles that use phenylalanine (F54) but …