Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
J Guo, X Huang, L Dou, M Yan, T Shen… - Signal Transduction and …, 2022 - nature.com
Aging is a gradual and irreversible pathophysiological process. It presents with declines in
tissue and cell functions and significant increases in the risks of various aging-related …
tissue and cell functions and significant increases in the risks of various aging-related …
The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
Cytoplasmic DNA: sources, sensing, and role in aging and disease
Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …
inflammation in diverse physiological and pathological contexts. Although the role of …
Aloe-emodin prevents nerve injury and neuroinflammation caused by ischemic stroke via the PI3K/AKT/mTOR and NF-κB pathway
M Xian, J Cai, K Zheng, Q Liu, Y Liu, H Lin, S Liang… - Food & function, 2021 - pubs.rsc.org
Ischemic stroke (IS) caused by cerebral arterial occlusion is the leading cause of global
morbidity and mortality. Cellular oxidative stress and inflammation play a vital role in the …
morbidity and mortality. Cellular oxidative stress and inflammation play a vital role in the …
Aging-associated and CD4 T-cell–dependent ectopic CXCL13 activation predisposes to anti–PD-1 therapy-induced adverse events
H Tsukamoto, Y Komohara, Y Tomita… - Proceedings of the …, 2022 - National Acad Sciences
Clinical success of immune-checkpoint blockade (ICB) cancer immunotherapy is
compromised by increased risk of immune-related adverse events (irAEs). However …
compromised by increased risk of immune-related adverse events (irAEs). However …
T cell fate decisions during memory cell generation with aging
The defense against infectious diseases, either through natural immunity or after
vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T …
vaccinations, relies on the generation and maintenance of protective T cell memory. Naïve T …
Functions of double‐negative B cells in autoimmune diseases, infections, and cancers
Most mature B cells can be divided into four subtypes based on the expression of the
surface markers IgD and CD27: IgD+ CD27− naïve B cells, IgD+ CD27+ unswitched memory …
surface markers IgD and CD27: IgD+ CD27− naïve B cells, IgD+ CD27+ unswitched memory …
[HTML][HTML] Mechanisms underpinning poor antibody responses to vaccines in ageing
J Le Lee, MA Linterman - Immunology letters, 2022 - Elsevier
Vaccines are a highly effective intervention for conferring protection against infections and
reducing the associated morbidity and mortality in vaccinated individuals. However, ageing …
reducing the associated morbidity and mortality in vaccinated individuals. However, ageing …
Ezh2 competes with p53 to license lncRNA Neat1 transcription for inflammasome activation
J Yuan, Q Zhu, X Zhang, Z Wen, G Zhang, N Li… - Cell Death & …, 2022 - nature.com
Inflammasome contributes to the pathogenesis of various inflammatory diseases, but the
epigenetic mechanism controlling its activation remains elusive. Here, we found that the …
epigenetic mechanism controlling its activation remains elusive. Here, we found that the …
RIPK1 blocks T cell senescence mediated by RIPK3 and caspase-8
T Imanishi, M Unno, N Yoneda, Y Motomura… - Science …, 2023 - science.org
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation. Here,
we show that T cell–specific RIPK1 deficiency in mice leads to the premature senescence of …
we show that T cell–specific RIPK1 deficiency in mice leads to the premature senescence of …